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In a previous post we noted the increasing importance of biologics as therapeutic agents, with 37% of the drugs approved by the FDA in 2017 being biologic entities. A recent article in Chemical & ...
ChemBio3D's overlay function is best known for small molecule overlay. In this video, we demonstrate that the same method applies to peptides. The demonstration includes: Open our standard sample file for human insulin and remove the water solvent. Download bovine insulin via ChemBio3D's online PDB ID lookup for ID=2ZP6. Paste the human insulin into the same ChemBio3D object as the bovine insulin. Select chain A from the bovine insulin as the "Target Fragment". Apply "Fast Overlay" to chain A from the human insulin. Observe that the primary structures for the two fragments are identical, but the tertiary structures differ. Show the human chain B and bovine chain B; they have been loosely overlaid along with the chain A's. Click here to update your profile.
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